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Web of Proceedings - Francis Academic Press
Web of Proceedings - Francis Academic Press

Research on Influences and Molecular Regulatory Mechanisms of miR-193b on Metastasis of Breast Cancer

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DOI: 10.25236/isbsbh.2018.009

Author(s)

Hongming Pan, Lihui Sun, Haiyan Zhang, Lin Li, Jie Lian, Jing Yu, Weiya Lang

Corresponding Author

Weiya Lang

Abstract

To investigate the effect of miR -193b on invasion and metastasis of breast cancer cells and its mechanism. MicroRNA array was used to detect the difference of microRNA expression profiles between breast cancer cells MDA-MB-231 and their lung high metastasis potential cell lines (MDA-MB-231-HM). Bioinformatics and other experimental methods are used to find the molecular targets of microRNA. Overexpression of microRNA-193b can reduce the expression efficiency of 3'UTR fluorescent plasmid with uPA. Moreover, microRNA-193b can inhibit the protein expression level of uPA without affecting its mRNA expression level. MiR-193b can inhibit the expression of uPA and aggravate the metastasis and invasion of breast cancer.

Keywords

Mir-193B, Upa, Breast Cancer