Author(s)

Jing Sun, Weijun Cao, Xianying Gai, Xiaofang Wang

Corresponding Author

Jing Sun

Abstract

The paper makes a comparative analysis of the clinical application value of exhaled nitric oxide (FeNO) in bronchial asthma combined with allergic rhinitis and simple bronchial asthma. It includes the comparison of the difference in FeNO measurement value, the correlation between FeNO and peripheral blood eosinophil percentage (EOS%), serum total specific antibody IgE (IgE) and lung function. In the paper, a total of 53 patients diagnosed and treated in Sijing Hospital of Shanghai Songjiang District were collected. The following groups were as follows: bronchial asthma complicated with allergic rhinitis group (AS+AR), 18 patients, simple bronchial asthma group (AS) 16 people, and control group 19 people. FeNO, peripheral blood EOS%, serum total IgE and lung function were measured respectively. Through SPSS statistical software analysis, it is concluded that there is a significant difference in terms of FeNO among AS+AR group, AS group and control group. The difference between AS+AR group and AS group is statistically significant (P<0.001), compared with those of AS group (three): the AS+AR group is higher than that of AS and control group, and the AS group is higher than that of the control group (22). There was a significant difference in EOS% between AS+AR group and AS group (P<0.001). There was a great difference between AS+AR group and control group (P<0.001). There was no significant difference between AS group and control group (P=0.102). The mean value of AS+AR group was higher than that of AS group and control group, and that of AS group was higher than that of control group. The total IgE was significantly different between the AS+AR group and the control group (P<0.01). There was a significant difference between the AS group and the control group (P<0.001). There was no significant difference between the AS+AR group and the AS group (P=0.751), the mean value: AS+AR group was higher than that of the AS group and the control group, and the AS group was higher than the control group. There was a significant difference between FEVl and FVC% in AS group and control group (P<0.01). There was a significant difference between AS+AR group and control group (P<0.05). There was no significant difference between AS group and AS+AR group (P=0.318). Mean: the control group was higher than that of AS+AR group and AS group, and the AS+AR group was higher than that of group AS. Index correlation: there is a significant positive correlation between FeNO and IgE (P<0.01); FeNO has a significant positive correlation with Eos% (P<0.01); FeNO has a significant negative correlation with FEV1/FVC% (P<0.01); there is a significant positive correlation between IgE and Eos% (IgE). Thus, FeNO is an objective index reflecting the chronic airway inflammation, objectively reflecting the degree of allergic airway inflammation, in time to assess the condition of patients with asthma, which is worthy of attention on allergic rhinitis; FeNO and EOS%, IgE, FEVl / FVC% complement each other, mutual influence, clinical the reference of diagnosis and treatment evaluation for allergic respiratory disease.

Keywords

Exhalation of Nitric Oxide, Allergic Rhinitis, Bronchial Asthma, Percentage of Eosinophils in Peripheral Blood, Serum Total IgE, Pulmonary Function.