Author(s)

Su Li

Corresponding Author

Su Li

Abstract

Objective: To study the stage of plasma cell mastitis and related inflammatory factors and the mechanism of its signaling pathway. Methods: Select the patients with cell mastitis to be tested (50 cases) as the research goal, and the income time is from August 2017 to September 2019; analyze TNF-α/NF-κB and IL6/JAK/STAT3 in the patient's tissues (Signal pathway) correlation and mechanism. Results: Compared with the patients in the chronic phase, the clinical levels of NF-κB, TNF-α, P-JAK, IL-6 and P-STAT3 in the acute phase and subacute phase clinical patients showed large differences, and the statistical value “P< 0.05”; In addition, TNF-α and NF-κB staining showed a large positive correlation, statistical value “P<0.05”; IL-6 and P-STAT3 staining showed a large positive correlation, statistical value “ P<0.05”. Conclusion: According to the stage of plasma cell mastitis patients, and the expression of related inflammatory factors show a certain correlation, and, TNF-α or NF-κB and IL-6 or JAK and STAT3 signaling pathway, etc., in plasma cells the occurrence and progress of patients with sexual mastitis have a certain impact.

Keywords

Staging of plasma cell mastitis, Related inflammatory factors, Signaling pathway, Mechanism