Author(s)

Xiaokun Sun, Xin Peng

Corresponding Author

Xin Peng

Abstract

Objective: This paper uses a systematic comprehensive evaluation to analyze and explore the relationship between smoking and drinking and the risk of esophageal cancer in China in recent years. And it provides a scientific theoretical basis for the prevention of esophageal cancer. Methods: This paper is based on the retrieval of three major domestic databases: CNKI database, Wanfang databases and knowledge service platform, and Chinese biomedical literature database. And it obtained all the literature of case-control studies on smoking and drinking and the risk of esophageal cancer published in China from January 2010 to January 2019. It selects the obtained articles through the inclusion and exclusion criteria, and uses the article quality evaluation tool to systematically evaluate and screen them. And this paper also uses Stata12.0 software to analyze the selected articles, such as sensitivity analysis, heterogeneity test, and publication bias and so on. And it also uses the fixed effect model to calculate the combined OR and 95%CI.Results: After a series of screening, a total of 12 articles were included. And the results of Meta analysis showed that there was no statistical heterogeneity among the studies. The calculation using the fixed effect model showed that the smoking OR value was 1.98 (95%CI=1.64～2.33), the drinking OR value was 2.13 (95%CI=1.78～2.48), and the combined OR value of smoking and drinking was 2.06 (95% CI=1.81～2.30).Conclusion: Smoking and drinking can significantly increase the risk of esophageal cancer. Compared with smoking, drinking is a greater risk factor for esophageal cancer.

Keywords

Meta analysis, esophageal cancer, smoking, drinking